Systemic Candidosis Diagnostic Test with Candida Score and Monocyte Count in Premature Infants with Late-Onset Sepsis: Research in Low Resources Country

Introduction. Candida is the cause of most systemic fungal infections that plays a role in pathophysiology sepsis newborns, especially premature infants with late-onset sepsis. The score can be used to assess occurrence candidosis where 2.5 accurately identify patients who are at high risk for candidiasis infection. Monocytes also play an important preventing candida invasion. Materials and methods. This study cross sectional research design. Data was collected from being suspected neonatology inpatient ward. It submitted period November-December 2021. takes minimum 31 samples meet criteria process analyze data. data obtained were processed analyzed using Receiver Operating Characteristic (ROC) method obtain Area Under Curve (AUC) value. Based on AUC curve, search optimal intersection carried out sensitivity specificity values. Results. Of subjects, number subjects positive PCR results 27 (76.93%) while negative 4 respondents (12.9%). mean value density group 76.93 range 40.23122.78. Meanwhile, negative, 0. diagnostic test showed 81%. Higher 70% found combined examination scores monocyte counts according cut-off compared separate examinations. Conclusions. count as sepsis, could consider initiation empirical antifungal therapy, either prophylactically or therapeutically, limited laboratory facilities Indonesia.